modafinil and anxiety looking for ways to reduce anxiety while taking modafinil, skip down to the section Coping With Modafinil-Induced Anxiety. Please also share your thoughts if you have personal experience with modafinil and anxiety. Modafinil, without a doubt, can cause anxiety. Modafinil made me anxious until I learned how to manage it, and it once caused a full-fledged panic attack. Overall, the drug is beneficial to me, and I will continue to purchase modafinil from AfinilExpress. So I devised some techniques to help me cope with anxiety while on modafinil. Modafinil increases adaptive stress by stimulating specific circuits in the HPA axis14. If you’ve ever taken an antihistamine, such as Benedryl, you know how drowsy they can be. Modafinil has the opposite effect, increasing wakefulness by increasing histamine rather than blocking it. Modafinil decreases GABA while increasing glutamate, dopamine, and orexin, in addition to histamine. Many factors influence whether or not you will experience anxiety while taking modafinil, including your baseline level of anxiety, genotype, and environment.- Pillspalace