Hydroxychloroquine can have certain negative side effects in addition to its beneficial ones. Although not all of these side effects are likely to occur, if they do, medical treatment may be required.

The following are the side effects (incidences not known)

·         Continual ringing or buzzing in the ears, or other unexplained noise

·         Skin darkening sensation of the continual movement of self or surrounds

·         Hair loss or thinning causes increased skin sensitivity to sunlight and irritation.

·         A decrease in appetite

·         Sense of spinning redness or other discoloration of the skin

·         Uncontrollable eye movements shakiness and unsteadiness while walking

·         Unsteadiness, tremors, or other muscle control or coordination issues

·         Weight loss due to vomiting

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Side Effects On Heart, Eyes, Stomach, and Skin

Heart:

ECG Changes (QT interval prolongation) in patients with specific risk factors has been reported in the cardiovascular system, which could lead to arrhythmia (torsade de Pointes, ventricular tachycardia).

Eyes:

Blurred vision is a common ocular symptom that affects 1 to 10% of people (including due to disturbance of accommodation).

Uncommon (0.1 percent to 1% of the population): Retinopathy (pigmentation changes, visual field defects), retinal abnormalities (paracentral, pericentral ring types, temporal scotomas, incorrect color vision), corneal changes (edema, opacities), haloes, photophobia.

Irreversible retinopathy with retinal discoloration changes (bull’s eye appearance), visual field defects (paracentral scotomas), visual disturbances (visual acuity), maculopathies (macular degeneration), decreased dark adjustment, color vision abnormalities, corneal changes (edema, opacities), drug corneal deposition with or without accompanying symptoms (halo around lights, photophobia, blurred vision), corneal deposition of drug with or without accompanying symptoms.

Blurred vision (temporary) and extraocular muscle palsies (reversible) were caused by a dose-dependent and reversible alteration of accommodation.

When the appropriate daily dose was not exceeded, retinopathy looked to be rare. When therapy was stopped, it appeared to be reversible in its early stages. Even after treatment discontinuation, if allowed to develop, there was a danger of progression.

Patients with retinal abnormalities were originally asymptomatic or had a scotomatous vision, including paracentral, pericentral, and temporal scotomas, as well as aberrant color vision.

Corneal abnormalities (including edema and opacities) have been reported anywhere from 3 weeks to many years after starting therapy. They could be asymptomatic or induce visual problems including haloes, impaired vision, or photophobia; they could be transitory and reversible when therapy was stopped.

Gastrointestinal (Stomach)

Very common (at least 10% of the time): Nausea and abdominal pain

Diarrhea and vomiting are common (1 percent to 10%).

When the dose was reduced or the medication was stopped, abdominal pain, nausea, diarrhea, and vomiting disappeared almost quickly.

Skin (Dermatologic)

When therapy was stopped, skin rash, pruritus, pigmentation issues in the skin and mucosal membranes, hair bleaching, and alopecia all went away quickly.

AGEP has to be separated from psoriasis, even though this medicine has triggered psoriasis flare-ups. Fever and hyperleukocytosis have been linked to AGEP. In general, the outcome after discontinuing this medicine was positive.

Skin rash, pruritus, and alopecia are all common (1 percent to 10%).

Pigmentary alterations, pigmentation problems in the skin and mucosal membranes, and hair bleaching are uncommon (0.1 percent to 1%).

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