Boofing drugs, sometimes also referred to as plugging drugs. It is the process of inserting drugs or alcohol into your anus to get a more immediate high. Because your anal cavity has a high number of blood vessels and a thinner surface layer, substances inserted into this area are absorbed in a faster rate than with oral consumption. People can boof several different drugs, including cocaine, MDMA, and alcohol, but there are several dangers of boofing drugs – it could even be fatal.