Electron Microscopy (EM) has become an extremely popular method for the ultrastructural study of macromolecules, cells, and tissues. An aqueous biological sample is frozen rapidly and irradiated with a beam of electrons. A detector senses how the electrons are scattered, and a computer reconstructs the 3D-shape of the molecule.
Cryo-EM company
Creative Biostructure is specialized in providing cost-effective contract services to both academia and biotech/pharmaceutical industries in the field of structural biology and membrane protein technologies. We have developed all-in-one, gene-to-structure pipelines for the structure determination of macromolecules of your interest. With a team of experienced professionals, Creative Biostructure is able to solve the structure of many challenging proteins including GPCRs, ion channels, transporters, enzymes and viral targets. We also provide a comprehensive list of products and other related services to facilitate your research in structural biology. Liposome Characterization Services https://www.creative-biostructure.com/Liposome-Analysis-and-Characterization-494.htm
Proteins are the executors of coronavirus infection in host cells. To understand the functions of specific proteins during infection, we need to study many aspects of proteins, such as protein interactions, protein modifications, and three-dimensional (3D) structures of proteins. In general, the premise of protein structural analysis is to obtain the target protein with high purity. For different applications and proteins with different properties, different protein expression and purification techniques are required to be adopted to obtain high-quality proteins. Nowadays, Creative Biostructure provides custom services for the expression and purification of soluble/membrane proteins involved in coronavirus research. SARS-CoV-2 Protein Purification https://www.creative-biostructure.com/coronavirus/protein-expression-and-purification-for-coronavirus-research-p12.htm
Virus-like particle (VLP) is a polymeric nanostructure assembled from natural viral structural proteins, but do not contain any genetic material. The VLP consists of high-density displays of viral surface proteins and is therefore a highly adaptable tool for a variety of applications, such as delivery system, antibody development, and membrane protein expression. During the coronavirus pandemic, Creative Biostructure rapidly integrated VLP-based vaccine development technologies and various in-house coronavirus-related VLP products to facilitate the development of methods for the prevention of this emerging infectious disease. COVID-19 VLP design https://www.creative-biostructure.com/coronavirus/vlp-based-vaccine-development-p33.htm