Protonitazene
Opioids are central nervous system depressants. They typically produce a range of effects including sedation, short-term pain relief, and respiratory depression (breathing difficulty).

Respiratory depression often appears more quickly with novel synthetic opioids (NSOs), increasing the risk of life-threatening overdose. NSOs are a leading contributor to overdose deaths worldwide

Protonitazene is a potent NSO that is not often seen in Australia. It’s around three times more potent than fentanyl and can produce life-threatening toxic effects in very small amounts.

What is Protonitazene?
As isotonitazene has only recently entered the European drug market, it is important to be aware that since some laboratories do not routinely screen for the substance, both its market presence and its role in serious adverse events (such as acute poisonings that present to hospital emergency rooms and medico-legal death investigations) may go undetected.

The fact that isotonitazene concentrations in biological samples are often low to sub-nanogram per milliliter is another problem, and it emphasizes the necessity for enhanced analytical sensitivity when testing for the substance.

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